Calcium release channel RyR2 regulates insulin release and glucose homeostasis
نویسندگان
چکیده
منابع مشابه
Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
The type 2 ryanodine receptor (RyR2) is a Ca2+ release channel on the endoplasmic reticulum (ER) of several types of cells, including cardiomyocytes and pancreatic β cells. In cardiomyocytes, RyR2-dependent Ca2+ release is critical for excitation-contraction coupling; however, a functional role for RyR2 in β cell insulin secretion and diabetes mellitus remains controversial. Here, we took advan...
متن کاملA simulation study of calcium release channel
The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The d...
متن کاملRole of high-voltage-activated calcium channels in glucose-regulated -cell calcium homeostasis and insulin release
Taylor, James T., Luping Huang, Brian M. Keyser, Hean Zhuang, Craig W. Clarkson, and Ming Li. Role of high-voltage-activated calcium channels in glucose-regulated -cell calcium homeostasis and insulin release. Am J Physiol Endocrinol Metab 289: E900–E908, 2005. First published June 14, 2005; doi:10.1152/ajpendo.00101.2005.—Highvoltage-activated (HVA) calcium channels are known to be the primary...
متن کاملEffects of diabetes on ryanodine receptor Ca release channel (RyR2) and Ca2+ homeostasis in rat heart.
The defects identified in the mechanical activity of the hearts from type 1 diabetic animals include alteration of Ca2+ signaling via changes in critical processes that regulate intracellular Ca2+ concentration. These defects result partially from a dysfunction of cardiac ryanodine receptor calcium release channel (RyR2). The present study was designed to determine whether the properties of the...
متن کاملa simulation study of calcium release channel
the ip3r calcium release channel has been simulated using a stochastic simulation algorithm (ssa;gillespie algorithm) and de young-keiser model. a set of different concentration for cat' and ip3 havebeen used. considering the number of molecules in each state, a non linear behavior of the system can beseen clearly. the inhibiting role of the ca+2 on the open state (x110) has been studied. the d...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2015
ISSN: 0021-9738,1558-8238
DOI: 10.1172/jci84937